| ncRNA name | PF-04523655 |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas and RPE/C tissues |
| Methods | qPCR, siRNA injection, dual-hybridization |
| Expression pattern | associated |
| Functional description | PF-04523655 administration decreased the incidence of clinical grade 3 or 4 lesions by approximately 60% (P = 0.053), and dose-dependently inhibited retinal RTP801 expression (P < 0.01). |
| PubMed ID | 24458146 |
| Year | 2014 |
| Title | RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801. |
| Drug-related ncRNA | NO |
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